Spurred on by Jim Bottomley, who put together one of the best offensive seasons in Major League history, the 1928 St. Louis Cardinals claimed their second National League pennant in three seasons. The Cardinals finised 95-59, outlasting two other 90-win teams in the New York Giants (93-69) and the Chicago Cubs (91-63) to advance to their second World Series.

Once again, the opponent was the New York Yankees. However, unlike 1926 when the Cardinals prevailed in their first Fall Classic appearance, the Yankees proved too tough and executed a four-game sweep. Bottomley carried the Cards all season as he hit .414 with 29 home runs and 130 RBI to claim the MVP award. Second baseman Frankie Frisch (.300, 86 RBI) and outfielder George Harper (.305, 17 HR) added to the attack.

Meanwhile, workhorse Pete Alexander had a steady season on the hill, going 16-9 with a 3.36 ERA while logging 243.2 innings.