During the offseason on November 6, the White Sox traded Josh Fields and Chris Getz to the Kansas City Royals for Mark Teahen. On November 6, the White Sox declined Jermaine Dye's 2010 Contract. On January 26, 2010, the White Sox had an opportunity to get Jim Thome back by signing a one-year deal with him, but passed, allowing him to then sign a one-year, $1.5 million contract with the Minnesota Twins. Thome had expressed interested in returning to Chicago, but White Sox manager Ozzie Guillen told Thome he wouldn't get enough at-bats to justify a return.
On the Opening Day, the White Sox shutout the Cleveland 6–0. On that day, Mark Buehrle made an astounding play when he hurried and picked up a ball with his glove in foul territory and quickly underthrew backwards with his glove to Paul Konerko, who caught the ball with his bare hand to force out Lou Marson in the fifth inning for the second out. Paul Konerko broke the franchise record for most home runs hit during the month of April with 11.
On May 11, the Sox opened the two-game series at the new Target Field and took the victory 5–2 over Minnesota, but the next day lost 3–2.
On June 13 against the Cubs at Wrigley Field, Gavin Floyd pitched a no-hitter through 6.2 innings before allowing a double to Alfonso Soriano and then the next batter scored Soriano by Chad Tracy's RBI single. The opposing pitcher Ted Lilly didn't allow a hit through 8+ innings before allowing a single to Juan Pierre. Later that inning, the bases were loaded, so it would have golden opportunities for Sox to score some runs, but failed. The Sox failed to sweep the Cubs as they lose 1–0 with one hit for Sox and three hits for Cubs. From June 12–20, they went eight straight games without hitting home runs, their longest since 1989, which they went nine straight homerless games. However, during their homerless streak, the Sox went 7–1, thanks to their starting pitching. During their span, the Sox have won six straight without hitting home runs for the first time since 1942. They have won eleven in a row for the first time since June 1961, which they have won twelve in a row.
On July 5–8, the Sox got their four-game sweep over the Los Angeles Angels for the first time since 1983. On July 11 against the Kansas City Royals, Andruw Jones hit his 400th career home run in third inning, 46th player in major league history to accomplish this feat. Also the Sox hit five home runs in the game, including four in third inning, tying their franchise history, including two back-to-backs. The Sox swept the Royals with a 15−5 victory and finished with a perfect homestand 7–0. From June 8 until the All-Star break, the Sox were 25–5, their best in MLB. On June 8, the Sox were 24–33 and 9½ games out of the first place. Just 40 days later, the Sox were 50–41 and were in first place by 1½ games over the Detroit Tigers. On July 18 against the Minnesota Twins at Target Field, the Sox led 6–3 going into the bottom of the ninth inning. Then the Twins scored four runs without getting anybody out and suffering Sox their first walk-off loss of the season. On July 23, Mark Buehrle celebrated one-year anniversary of his perfect game by taking a complete game victory over the Oakland Athletics in Oakland. He allowed 1 earned run, 4 hits, 0 walk and 2 strikeouts. From July 26–29, the Sox swept the four-game series over the Seattle Mariners for the first time since 1994 and finished the season series versus the Mariners 9–1 and outscoring them 52–21.
On August 3, the Sox played a split doubleheader at Detroit, which the Sox won 12–2 in afternoon game and lost 7–1 in night game. The afternoon game was a made-up game from May 17. The next day, Edwin Jackson made his White Sox debut against his former teammate, which he went 7.0 IP, 9 H, ER, BB, 6 K. Jackson got his first win with the White Sox since moving from Arizona against Armando Galarraga, whose perfect game was lost by the blown call by an umpire on June 2. Jackson threw a no-hitter against the Tampa Bay Rays in St. Petersburg, Florida on June 25. After that game, the Sox were 37–13 (.740) over their last 50 games since June 8, best record in MLB during that span. From August 10–12, the Sox lost the series against the Twins and fell to 2nd place in the AL Central one game back. Also the Sox lost the series at home for the first time since June 4–6 against the Indians, snapping their 7 straight home series wins. During the span of time between series losses at home, the Sox were 20–3 while the Sox swept four opponents. From August 17–19, the Sox played a big series against the rival Twins at Target Field when the Sox were three games behind the first place Twins prior to the first game. In the first game, the former White Sox teammate Jim Thome hit a walk-off two-run homer off of Matt Thornton in the tenth inning to down the White Sox 7–6. In the second game, the Twins beat the Sox again 7–6. And then in the third game, the Sox blew out the Twins 11–0 to avoid sweep. The Sox snapped their Twins 9-game home winning streak and they snapped their 5-game losing streak at Target Field. On August 29, The White Sox hosted Frank Thomas day at U.S. Cellular field against the New York Yankees. Frank Thomas's Jersey was retired that day. The White Sox Organization also printed his face on the legendary wall in Left-Center field with other number retirees Billy Pierce to his left and Carlton Fisk to his right. Thomas's image also appears under the printed words 'The Catch,' commemorating DeWayne Wise's catch to preserve Mark Buehrle's perfect game in 2009. On August 30, Chicago acquired Manny Ramírez off waivers from the Los Angeles Dodgers.
On September 3, the game in Boston was postponed due to Hurricane Earl. On September 4, the White Sox swept the doubleheader at Red Sox with identical scores 3–1 with both saves from Bobby Jenks. It is the first time the White Sox swept the doubleheader in Boston since 1991. Then on September 5, the White Sox swept the Red Sox at Fenway Park for their first time since July 27–28, 1991 when the Sox came back with four runs in the top of the ninth inning to take a 7–5 lead, all with two outs. Also, Manny Ramírez faced his former team, against which he went 3–8 combined in this series. On September 12, Paul Konerko hit two two-run homers and five RBIs, recording his fourth career 30 homer/100 RBI season. From September 14–16, the Sox got swept by Twins at home, losing 9 of their last 11 home games against these Twins. With that sweep, the Sox fell to nine games back and Twins outscored the Sox 26–11. Then the next series against the Tigers at home, the Sox got swept again. The Sox got swept by Tigers at home for the first time since 2001. Then the Sox swept the Angels in Los Angeles for the first time since April 2006. In this series, the Sox outscored the Angels 12–6 and finished the season series against the Angels 7–2 and won seven in a row against them. They finished the season road record 43–38 (4th best in AL, 3rd best since 1999), better than last year's 36–45. In this season, the Sox swept five opponents on the road compared to two last season, four of them are the losing teams. On September 28 against the Boston Red Sox, Dayán Viciedo gave the White Sox their first walk-off hit since April 24, winning it 5–4, which came back from a 3–0 deficit. It is only the third walk-off win this season which trails the majors against seven walk-off losses, all since the All-Star break.By WIKI
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