| Title | G | W | L | ERA | IP | SO | BB | H | HR | GS | ER | R | CG | SHO | GF | SV |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dillon Gee | 5 | 2 | 2 | 2.180 | 33 | 17 | 15 | 25 | 2 | 5 | 8 | 10 | 0 | 0 | 0 | 0 |
| Francisco Rodriguez | 53 | 4 | 2 | 2.200 | 57 | 67 | 21 | 45 | 3 | 0 | 14 | 14 | 0 | 0 | 46 | 25 |
| Elmer Dessens | 53 | 4 | 2 | 2.300 | 47 | 16 | 16 | 41 | 4 | 0 | 12 | 14 | 0 | 0 | 6 | 0 |
| Bobby Parnell | 41 | 0 | 1 | 2.830 | 35 | 33 | 8 | 41 | 1 | 0 | 11 | 13 | 0 | 0 | 10 | 0 |
| R.A. Dickey | 27 | 11 | 9 | 2.840 | 174 | 104 | 42 | 165 | 13 | 26 | 55 | 62 | 2 | 1 | 0 | 0 |
| Manny Acosta | 41 | 3 | 2 | 2.950 | 40 | 42 | 18 | 30 | 4 | 0 | 13 | 13 | 0 | 0 | 12 | 1 |
| Johan Santana | 29 | 11 | 9 | 2.980 | 199 | 144 | 55 | 179 | 16 | 29 | 66 | 67 | 4 | 2 | 0 | 0 |
| Pedro Feliciano | 92 | 3 | 6 | 3.300 | 63 | 56 | 30 | 66 | 1 | 0 | 23 | 24 | 0 | 0 | 16 | 0 |
| Hisanori Takahashi | 53 | 10 | 6 | 3.610 | 122 | 114 | 43 | 116 | 13 | 12 | 49 | 51 | 0 | 0 | 21 | 8 |
| Mike Pelfrey | 34 | 15 | 9 | 3.660 | 204 | 113 | 68 | 213 | 12 | 33 | 83 | 88 | 0 | 0 | 1 | 1 |
| Patrick Misch | 12 | 0 | 4 | 3.820 | 38 | 23 | 4 | 43 | 4 | 6 | 16 | 20 | 0 | 0 | 2 | 0 |
| Sean Green | 11 | 0 | 0 | 3.860 | 9 | 12 | 8 | 7 | 1 | 0 | 4 | 6 | 0 | 0 | 0 | 0 |
| Tobi Stoner | 1 | 0 | 1 | 3.860 | 2 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| Jonathon Niese | 30 | 9 | 10 | 4.200 | 174 | 148 | 62 | 192 | 20 | 30 | 81 | 97 | 2 | 1 | 0 | 0 |
| Jenrry Mejia | 33 | 0 | 4 | 4.620 | 39 | 22 | 20 | 46 | 3 | 3 | 20 | 21 | 0 | 0 | 8 | 0 |
| Raul Valdes | 38 | 3 | 3 | 4.910 | 59 | 56 | 27 | 59 | 7 | 1 | 32 | 33 | 0 | 0 | 8 | 1 |
| Fernando Nieve | 40 | 2 | 4 | 6.00 | 42 | 38 | 22 | 37 | 10 | 1 | 28 | 28 | 0 | 0 | 9 | 0 |
| John Maine | 9 | 1 | 3 | 6.130 | 40 | 39 | 25 | 47 | 8 | 9 | 27 | 29 | 0 | 0 | 0 | 0 |
| Oliver Perez | 17 | 0 | 5 | 6.800 | 46 | 37 | 42 | 54 | 9 | 7 | 35 | 37 | 0 | 0 | 4 | 0 |
| Ryota Igarashi | 34 | 1 | 1 | 7.120 | 30 | 25 | 18 | 29 | 4 | 0 | 24 | 24 | 0 | 0 | 11 | 0 |
