| Title | G | W | L | ERA | IP | SO | BB | H | HR | GS | ER | R | CG | SHO | GF | SV |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dan Runzler | 11 | 0 | 0 | 1.040 | 9 | 11 | 5 | 6 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| Jeremy Affeldt | 74 | 2 | 2 | 1.730 | 62 | 55 | 31 | 42 | 3 | 0 | 12 | 14 | 0 | 0 | 8 | 0 |
| Madison Bumgarner | 4 | 0 | 0 | 1.800 | 10 | 10 | 3 | 8 | 2 | 1 | 2 | 2 | 0 | 0 | 1 | 0 |
| Tim Lincecum | 32 | 15 | 7 | 2.480 | 225 | 261 | 68 | 168 | 10 | 32 | 62 | 69 | 4 | 2 | 0 | 0 |
| Brad Penny | 6 | 4 | 1 | 2.590 | 42 | 20 | 9 | 31 | 5 | 6 | 12 | 13 | 1 | 0 | 0 | 0 |
| Brian Wilson | 68 | 5 | 6 | 2.740 | 72 | 83 | 27 | 60 | 3 | 0 | 22 | 27 | 0 | 0 | 60 | 38 |
| Matt Cain | 33 | 14 | 8 | 2.890 | 218 | 171 | 73 | 184 | 22 | 33 | 70 | 73 | 4 | 0 | 0 | 0 |
| Brandon Medders | 61 | 5 | 1 | 3.010 | 69 | 58 | 32 | 63 | 6 | 0 | 23 | 26 | 0 | 0 | 11 | 1 |
| Justin Miller | 44 | 3 | 3 | 3.180 | 57 | 36 | 27 | 47 | 7 | 0 | 20 | 20 | 0 | 0 | 6 | 0 |
| Bobby Howry | 63 | 2 | 6 | 3.390 | 64 | 46 | 23 | 50 | 5 | 0 | 24 | 26 | 0 | 0 | 20 | 0 |
| Sergio Romo | 45 | 5 | 2 | 3.970 | 34 | 41 | 11 | 30 | 1 | 0 | 15 | 15 | 0 | 0 | 9 | 2 |
| Barry Zito | 33 | 10 | 13 | 4.030 | 192 | 154 | 81 | 179 | 21 | 33 | 86 | 89 | 1 | 0 | 0 | 0 |
| Waldis Joaquin | 10 | 0 | 0 | 4.220 | 11 | 12 | 7 | 10 | 1 | 0 | 5 | 5 | 0 | 0 | 4 | 0 |
| Jonathan Sanchez | 32 | 8 | 12 | 4.240 | 163 | 177 | 88 | 135 | 19 | 29 | 77 | 82 | 1 | 1 | 2 | 0 |
| Ryan Sadowski | 6 | 2 | 4 | 4.450 | 28 | 17 | 17 | 28 | 2 | 6 | 14 | 15 | 0 | 0 | 0 | 0 |
| Randy Johnson | 22 | 8 | 6 | 4.880 | 96 | 86 | 31 | 97 | 19 | 17 | 52 | 55 | 0 | 0 | 2 | 0 |
| Merkin Valdez | 48 | 2 | 1 | 5.660 | 49 | 38 | 28 | 57 | 5 | 0 | 31 | 33 | 0 | 0 | 20 | 0 |
| Joe Martinez | 9 | 3 | 2 | 7.500 | 30 | 19 | 12 | 46 | 4 | 5 | 25 | 27 | 0 | 0 | 1 | 0 |
| Osiris Matos | 5 | 0 | 0 | 9.00 | 6 | 5 | 1 | 11 | 2 | 0 | 6 | 7 | 0 | 0 | 2 | 0 |
| Patrick Misch | 4 | 0 | 0 | 10.800 | 3 | 0 | 3 | 6 | 0 | 0 | 4 | 4 | 0 | 0 | 2 | 0 |
| Alex Hinshaw | 9 | 0 | 0 | 12.00 | 6 | 2 | 7 | 10 | 2 | 0 | 8 | 8 | 0 | 0 | 3 | 0 |
