| Title | G | W | L | ERA | IP | SO | BB | H | HR | GS | ER | R | CG | SHO | GF | SV |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jae Kuk Ryu | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Kurt Birkins | 6 | 0 | 0 | .900 | 10 | 7 | 5 | 5 | 0 | 0 | 1 | 1 | 0 | 0 | 2 | 0 |
| Chad Bradford | 21 | 1 | 0 | 1.420 | 19 | 4 | 8 | 18 | 1 | 0 | 3 | 3 | 0 | 0 | 4 | 0 |
| Grant Balfour | 51 | 6 | 2 | 1.540 | 58 | 82 | 24 | 28 | 3 | 0 | 10 | 10 | 0 | 0 | 12 | 4 |
| David Price | 5 | 0 | 0 | 1.930 | 14 | 12 | 4 | 9 | 1 | 1 | 3 | 4 | 0 | 0 | 0 | 0 |
| J.P. Howell | 64 | 6 | 1 | 2.220 | 89 | 92 | 39 | 62 | 6 | 0 | 22 | 29 | 0 | 0 | 9 | 3 |
| Dan Wheeler | 70 | 5 | 6 | 3.120 | 66 | 53 | 22 | 44 | 10 | 0 | 23 | 25 | 0 | 0 | 26 | 13 |
| Scott Kazmir | 27 | 12 | 8 | 3.490 | 152 | 166 | 70 | 123 | 23 | 27 | 59 | 61 | 0 | 0 | 0 | 0 |
| James Shields | 33 | 14 | 8 | 3.560 | 215 | 160 | 40 | 208 | 24 | 33 | 85 | 94 | 3 | 2 | 0 | 0 |
| Matt Garza | 30 | 11 | 9 | 3.700 | 185 | 128 | 59 | 170 | 19 | 30 | 76 | 83 | 3 | 2 | 0 | 0 |
| Trever Miller | 68 | 2 | 0 | 4.150 | 43 | 44 | 20 | 39 | 2 | 0 | 20 | 21 | 0 | 0 | 16 | 2 |
| Al Reyes | 26 | 2 | 2 | 4.370 | 23 | 19 | 10 | 21 | 2 | 0 | 11 | 12 | 0 | 0 | 6 | 0 |
| Andy Sonnanstine | 32 | 13 | 9 | 4.380 | 193 | 124 | 37 | 212 | 21 | 32 | 94 | 105 | 1 | 1 | 0 | 0 |
| Edwin Jackson | 32 | 14 | 11 | 4.420 | 183 | 108 | 77 | 199 | 23 | 31 | 90 | 91 | 0 | 0 | 0 | 0 |
| Troy Percival | 50 | 2 | 1 | 4.530 | 46 | 38 | 27 | 29 | 9 | 0 | 23 | 26 | 0 | 0 | 38 | 28 |
| Jason Hammel | 40 | 4 | 4 | 4.600 | 78 | 44 | 35 | 83 | 11 | 5 | 40 | 45 | 0 | 0 | 21 | 2 |
| Jeff Niemann | 5 | 2 | 2 | 5.060 | 16 | 14 | 8 | 18 | 3 | 2 | 9 | 12 | 0 | 0 | 2 | 0 |
| Gary Glover | 29 | 1 | 2 | 5.820 | 34 | 22 | 18 | 42 | 3 | 0 | 22 | 22 | 0 | 0 | 10 | 0 |
| Scott Dohmann | 12 | 2 | 0 | 6.140 | 15 | 12 | 7 | 18 | 2 | 0 | 10 | 10 | 0 | 0 | 6 | 0 |
| Juan Salas | 5 | 0 | 0 | 7.110 | 6 | 8 | 4 | 5 | 0 | 0 | 5 | 5 | 0 | 0 | 2 | 0 |
| Mitch Talbot | 3 | 0 | 0 | 11.170 | 10 | 5 | 11 | 16 | 3 | 1 | 12 | 12 | 0 | 0 | 0 | 0 |
