In spring training the Rays finished with the best record in the Grapefruit League and set a franchise record for wins in spring training. Second baseman Sean Rodriguez, who had been acquired in the Scott Kazmir trade with the Angels, was considered a breakout player during the spring, on both the offensive and defensive side of the ball.
Although the Rays had the league best record at the time, Dallas Braden of the Oakland Athletics threw a perfect game against the Rays in May. It was the league's second perfect game in a row thrown against Tampa Bay, the last being in 2009 by Mark Buerhle, and at the time was the shortest amount of time between perfect games in Major League Baseball. The Rays were once again victims of a no-hitter on June 25 at Tropicana Field, thrown by former Ray, Edwin Jackson of the Arizona Diamondbacks. Jackson threw 149 pitches against his old team, and although 10 batters reached base, none were the result of a base hit.
David Price, Evan Longoria, Carl Crawford, and Rafael Soriano were named to the American League team in the 2010 All-Star game. Price was named the starting pitcher for the AL.
On July 26, 2010, Matt Garza threw a no-hitter against the Detroit Tigers, becoming the fifth pitcher to throw a no-hitter that season. It was the first no-hitter ever thrown by a Tampa Bay pitcher in the franchise's history.
On the last day of the regular season, the Rays won their second AL East championship in three years, and finished the 2010 season with the American League's best record (96–66), and behind only the Philadelphia Phillies by one game for the Majors' best record. The Rays' ace pitcher David Price finished with 19 wins, and closer Rafael Soriano converted 45 saves, both setting new franchise records in those respective categories.
In the postseason, the Rays were eliminated in the ALDS, losing to the Texas Rangers in five games.By WIKI